Product Profile

Product Name	Anti-ABCG2 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	ABCG2
Gene Synonyms	MRX MXR ABCP BCRP BMDP MXR1 ABC15 BCRP1 CD338 GOUT1 MXR-1 CDw338 UAQTL1 EST157481 Hide
Gene Full Name	ATP binding cassette subfamily G member 2 (Junior blood group)
Gene Summary	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Hide
Molecular Weight(MW)	72 kDa, 67 kDa（Observed:140 kDa Homodimer)
Cellular Localizatio	Cell membrane, Membrane, Mitochondrion

Application

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WB

Western blot analysis using ABCG2 antibody against Hela(1), A431(2), HepG2(3) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using ABCG2 antibody with DAB staining.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.