Product Profile

Product Name	Anti-PERK antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHC
	IHC:1:200-1:2000
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	EIF2AK3
Gene Synonyms	PEK WRS PERK
Gene Full Name	eukaryotic translation initiation factor 2 alpha kinase 3
Gene Summary	The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] Hide
Molecular Weight(MW)	125KD
Cellular Localizatio	Endoplasmic reticulum

Application

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IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using PERK antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using PERK antibody with DAB staining.

Application Notes

IHC:1:200-1:2000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.