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| 产地 | 上海 |
| 保存条件 | 密封于-20oC阴凉干燥环境。 |
| 品牌 | DUMABIO |
| 货号 | 电询 |
| 用途 | 科研与实验 |
| 检测方法 | 电询 |
| 保质期 | 2年 |
| 适应物种 | 电询 |
| 检测限 | 电询 |
| 数量 | 1000 |
| 包装规格 | 1g |
| 标记物 | 无 |
| 样本 | 电询 |
| 应用 | 科研试剂 |
| 是否进口 | 否 |
Anti-PSD95 (phospho S418)抗体[EPR2618Y]
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重组ANTI-PSD95 (PHOSPHO S418)抗体[EPR2618Y] |
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Anti-PSD95 (phospho S418)抗体[EPR2618Y] |
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抗PSD95(磷酸S418)抗体[EPR2618Y] |
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279.3154 |
背景:
Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. PSD contains receptors with associated signaling- and scaffolding-proteins that organize signal-transduction pathways near the post-synaptic membrane (2). As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, learning and memory, with its phosphorylation being critical for regulation of its function (3).REFERENCES1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.2. Yamauchi T, et al. MSR 21(4):266-286, 2003.3. Kim MJ, et al. Neuron 56: 488-502, 2007.
其他名字:
DLG4, PSD95, Disks large homolog 4, Synapse-associated protein 90
克隆名:
EPR2618Y
靶点信息
基因id:
1742
蛋白名:
DLG4
胞内定位:
Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells
同义词:
PSD95
应用与保存
稀释浓度:
WB~~1:500
注意事项:
PSD95 Antibody Phospho (pS418) is for research use only and not for use in diagnostic or therapeutic procedures.
其他
参考文献:
1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.2. Yamauchi T, et al. MSR 21(4):266-286, 2003.3. Kim MJ, et al. Neuron 56: 488-502, 2007.
保存条件:
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
标记物:
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
主要序列号:
P78352
分子量:
80495 Da
功能:
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Anti-PSD95 (phospho S418)抗体[EPR2618Y]

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