产品展厅
Anti-PSD95 (phospho S418)抗体[EPR2618Y]
  • 品牌:DUMABIO
  • 产地:上海
  • 型号:1g
  • 货号:电询
  • 发布日期: 2024-01-15
  • 更新日期: 2026-01-19
产品详请
产地 上海
保存条件 密封于-20oC阴凉干燥环境。
品牌 DUMABIO
货号 电询
用途 科研与实验
检测方法 电询
保质期 2年
适应物种 电询
检测限 电询
数量 1000
包装规格 1g
标记物
样本 电询
应用 科研试剂
是否进口

Anti-PSD95 (phospho S418)抗体[EPR2618Y]

重组ANTI-PSD95 (PHOSPHO S418)抗体[EPR2618Y]
Anti-PSD95 (phospho S418)抗体[EPR2618Y]
抗PSD95(磷酸S418)抗体[EPR2618Y]
279.3154


背景: Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. PSD contains receptors with associated signaling- and scaffolding-proteins that organize signal-transduction pathways near the post-synaptic membrane (2). As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, learning and memory, with its phosphorylation being critical for regulation of its function (3).REFERENCES1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.2. Yamauchi T, et al. MSR 21(4):266-286, 2003.3. Kim MJ, et al. Neuron 56: 488-502, 2007.
其他名字: DLG4, PSD95, Disks large homolog 4, Synapse-associated protein 90
克隆名: EPR2618Y

靶点信息

基因id: 1742
蛋白名: DLG4
胞内定位: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells
同义词: PSD95

应用与保存

稀释浓度: WB~~1:500
注意事项: PSD95 Antibody Phospho (pS418) is for research use only and not for use in diagnostic or therapeutic procedures.

其他

参考文献: 1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.2. Yamauchi T, et al. MSR 21(4):266-286, 2003.3. Kim MJ, et al. Neuron 56: 488-502, 2007.
保存条件: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
标记物: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
主要序列号: P78352
分子量: 80495 Da
功能: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

Anti-PSD95 (phospho S418)抗体[EPR2618Y]


科研ELISA是上海笃玛生物的主营产品,科研ELISA栏目提供该类目产品说明书以及提供产品报价与网上订购。

上海笃玛生物科技有限公司经过数年的努力发展已迅速成为集产品研发、生产、经营为一体的专业化生物工程公司。公司具有完善的实验技术开发平台,成熟的抗原、抗体研发系统,熟练掌握各种酶联技术,结合公司的研发团队,可以有效的保证公司产品强的稳定性和高的准确性,同时又具有竞争力的价格。

公司目前主要提供生化试剂、分子生物学试剂及试剂盒,各种抗体及免疫学试剂盒、实验耗材等多门类上万种产品,产品涉及分子生物学、细胞生物学、免疫学等生命科学的各个领域。

新闻资讯
联系方式
手机:15214367449
Q Q:
微信扫一扫