Biofunctionalized fluorescent nanodiamonds are infinitely photostable labels for fluorescent and multiphoton microscopy applicable to cellular tracking and long-term observation of biological processes in the same fields of view in live cell-imaging and fixed cells. Protein, antibody, biologically active organic molecules, and custom functionalizations are possible. We provide nanodiamonds with nitrogen-vacancy (NV) centers with red-to-near-infrared fluorescence, NVN centers with green fluorescence, and novel particles available only at Adamas with a combination of NV and NVN centers within a single particle with visual yellow fluorescence. Fluorescence from NV centers can be magnetically modulated providing a means to eliminate the fluorescent background by image subtraction and to significantly enhance the signal-to-noise ratio. This property can be very useful in future biosensing applications, for example in clinical diagnostics such as lateral flow assays (LFA). Relevant applications also include super-resolution microscopy, multiphoton microscopy, time-gated microscopy and correlative microscopy.

 

Fluorescent nanodiamonds are a chemically robust, infinitely photostable, and biocompatible fluorophore with a range of functional surface chemistries. Relevant applications include fiducial marking, super-resolution microscopy, multiphoton microscopy, time-gated microscopy, and correlative microscopy.

Below is our selection of nitrogen-vacancy (NV) nanodiamonds centers with red-to-near-infrared fluorescence with a variety of surface functionalities. Negatively charged nitrogen-vacancy (NV-) centers possess an electron spin with unique magneto-optical properties: the spin state can be detected optically via optically detected magnetic resonance (ODMR). In turn, the spin state is highly sensitive to the surrounding environment so that changes in the environment can be detected via changes in nitrogen-vacancy (NV) fluorescence. Based on these properties, our customers develop nanodiamond-based quantum sensors of magnetic fields, electric currents, temperature, free radicals, and other phenomena.

Design your own downstream reaction schemes, or contact us for specific custom functionalities.