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查找：Anti-Tyrosine Hydroxylase Antibody
  • 品牌：DUMABIO
  • 产地：上海
  • 型号：1mg
  • 货号：电询
  • 发布日期： 2024-01-17
  • 更新日期： 2026-01-19
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产品详请
产地 上海
保存条件 密封于-20oC阴凉干燥环境。
品牌 DUMABIO
货号 电询
用途 科研与实验
检测方法 电询
保质期 2年
适应物种 电询
检测限 电询
数量 1000
包装规格 1mg
标记物 无
样本 电询
应用 科研试剂
是否进口 否


查找：Anti-Tyrosine Hydroxylase Antibody


描述
Tyrosine Hydroxylase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 59 kDa, targeting to Tyrosine Hydroxylase. It can be used for WB,ICC,IHC-P,FC,IF assays with tag free, in the background of Human, Mouse, Rat.

标签
Free

分子量
Predicted band size: 59 kDa

纯度
Protein A affinity purified.

亚细胞定位
Cytoplasm.

偶联
Non-conjugated

研究领域
Neuroscience

产品类别
Primary Antibody; Rabbit Monoclonal Antibody

宿主
Rabbit

反应物种
Human, Mouse, Rat

蛋白数据库
SwissProt: P07101 Human;SwissProt: P24529 Mouse;SwissProt: P04177 Rat

推荐稀释比例
WB: 1:1,000-1:10,000 ;ICC: 1:50-1:200 ;IHC-P: 1:2,000 ;FC: 1:50-1:100 ;IF: 1:200

应用
WB, ICC, IHC-P, FC, IF

性状
液体

组分
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.

保存条件 & 期限
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

运输条件
Shipping with blue ice.

同型
IgG

免疫原
Synthetic peptide corresponding to Human Tyrosine Hydroxylase.The exact sequence is proprietary to MCE.

查找：Anti-Tyrosine Hydroxylase Antibody

功能
Plays an important role in the physiology of adrenergic neurons.
组织特异性
Mainly expressed in the brain and adrenal glands.
通路
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
疾病相关
Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
序列相似性
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Target information above from: UniProt accession P07101
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010


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