查找：ANTI-AMYLOID PRECURSOR PROTEIN, PEPTIDE #3, #4, #5 ANTIBODY

产品名称淀粉样前体蛋白(amyloid precursor protein，APP)是一种广泛存在于全身组织细胞上的单次跨膜蛋白，其经蛋白酶裂解后会产生具有毒性作用的β-淀粉样蛋白，迄今为止人们对APP真正的生理功能仍知之甚少。

淀粉样前体蛋白(amyloid precursor protein，APP)是一种广泛存在于全身组织细胞上的单次跨膜蛋白，因其经蛋白酶裂解后产生具有毒性作用的β-淀粉样蛋白(β-amyloid，Aβ)而广受关注，但迄今为止人们对APP真正的生理功能仍知之甚少，许多学者认为APP裂解后形成的Aβ沉积所形成的是AD的重要原因

查找：ANTI-AMYLOID PRECURSOR PROTEIN, PEPTIDE #3, #4, #5 ANTIBODY

Target Protein:
Amyloid Precursor Protein

IR:
Immunogen Range:381-480/770

Clonality:
Polyclonal

Isotype:
IgG

Entrez Gene:
351

Swiss Prot:
P05067

Source:
KLH conjugated synthetic peptide derived from of human APP:381-480/770

Purification:
affinity purified by Protein A

Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Size:
50ul

Concentration:
1mg/ml

Applications:
WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100)
IF(1:100-500)

Cross Reactive Species:
Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
Sheep

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仅供科研使用。不能用于人和动物 等其它临床诊断用！