说明

一般描述

The KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit enables chemists to quickly and efficiently screen reaction conditions for Pd catalyzed Miyaura borylation reactions. Quick identification of optimal conditions allows faster scale-up of the desired synthetic transformation. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

应用

Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Miyaura Borylation Reaction Screening Kit
Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:

• 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
• 4 x 4 mL reaction vials with pre-weighed KOAc
• Bis(pinacolato)diboron (473294 ), tetrahydroxydiboron (754242 ), and pinacol (221171 )
• 1 (2 mL) ampule each of toluene, THF, n-butanol, DMA, MeOH, MeCN, ethylene glycol and DIPEA.
• 1 NEW KitAlysis 24-Well Reaction Block Replacement Film.
• 4 stir bars for substrate stock solution vials.
• 1 internal standard.

Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box  and 24-well Reaction Block  (sold separately).

特点和优势

• Designed and tested by synthetic chemists.
• Easily run 24-microscale reactions in parallel.
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.