Product Name

Anti-Interleukin 1 beta antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Clonality

Polyclonal

Isotype

IgG

Host Species

Human

Tested Applications

ELISAIHCWB

WB:1:200-1:2000
IHC:1:200-1:1000

Species Reactivity

GoatHumanMouseRat

Concentration

1.0mg/ml

Purification

Protein A

Gene Symbol

IL1B interleukin 1 beta

Gene Synonyms

IL-1
IL1F2
IL1beta
IL1-BETA

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Gene Full Name

interleukin 1 beta

Gene Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]

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Molecular Weight

31 kDa

Source

Rabbit

Cellular Localizatio

Cytoplasm>Cytosol. Lysosome. Secreted>Extracellular exosome. Secreted.

Application Notes

WB:1:200-1:2000
IHC:1:200-1:1000

Form

Liquid

Storage Instruction

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azide.