Product Profile

Product Name	Anti-SHP-1 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	PTPN6
Gene Synonyms	HCP HCPH SHP1 SHP-1 HPTP1C PTP-1C SHP-1L SH-PTP1 Hide
Gene Full Name	protein tyrosine phosphatase non-receptor type 6
Gene Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] Hide
Molecular Weight(MW)	67 KDa
Source	Rabbit
Cellular Localizatio	Cytoplasm. Nucleus.

Application

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WB

Western blot analysis using SHP-1 antibody against HepG2 (1), PC-3 (2), SK-OV-3 (3) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded colon cancer tissues using SHP-1 antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of NIH/3T3 cells using SHP-1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.