Product Profile

Product Name	Anti-Cox1 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	PTGS1
Gene Synonyms	COX1 COX3 PHS1 PCOX1 PES-1 PGHS1 PTGHS PGG/HS PGHS-1 Hide
Gene Full Name	prostaglandin-endoperoxide synthase 1
Gene Summary	This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Hide
Molecular Weight(MW)	70 KDa（Observed: 55 kDa）
Source	Rabbit
Cellular Localizatio	Microsome membrane. Endoplasmic reticulum membrane.

Application

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WB

Western blot analysis using Cox1 antibody against B16 (1), PC-3 (2) cell lysate.

·        

IHC

Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using Cox1 antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of A549 cells using Cox1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.