Product Profile

Product Name	Anti-TNFRSF11B antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	TNFRSF11B
Gene Synonyms	OPG TR1 OCIF PDB5 Hide
Gene Full Name	TNF receptor superfamily member 11b
Gene Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Hide
Molecular Weight(MW)	46 KDa
Source	Rabbit
Cellular Localizatio	Secreted

Application

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WB

Western blot analysis using TNFRSF11B antibody against HUVEC (1), Jurkat (2), MCF-7 (3), NIH3T3 (4) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded breast cancer tissues using TNFRSF11B antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of Hela cells using TNFRSF11B antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.