Product Profile

Product Name	Anti-Filamin A antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	FLNA
Gene Synonyms	FLN FMD MNS OPD ABPX CSBS CVD1 FGS2 FLN1 NHBP OPD1 OPD2 XLVD XMVD FLN-A ABP-280 Hide
Gene Full Name	filamin A
Gene Summary	The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] Hide
Molecular Weight(MW)	281 kDa
Cellular Localizatio	Cell projection, Cytoplasm, Cytoskeleton

Application

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WB

Western blot analysis using Filamin A antibody against Hela(1), A549(2) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using Filamin A antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of SK-OV-3 cells using Filamin A antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.