产品展厅
Anti-MBD2 antibody
  • 品牌:OminimAbs
  • 产地:上海
  • 型号:毫升
  • 货号:OM641708
  • 发布日期: 2024-09-04
  • 更新日期: 2024-10-09
产品详请
产地 上海
品牌 OminimAbs
保存条件
货号 OM641708
用途 实验研究
应用范围 科研实验
抗原来源 电询
保质期 2年
抗体名 电询
是否单克隆
克隆性
靶点 电询
适应物种 电询
形态 电询
宿主 电询
标记物 电询
包装规格 毫升
亚型 电询
标识物 电询
浓度 电询%
免疫原 电询
是否进口

Product Profile

Product Name

Anti-MBD2 antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Key Feature

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Application

ELISAICC/IFIHCWB

WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500

Species Reactivity

HumanMouseRat

Concentration

1 mg/ml

Purification

Protein A

Target Information

Gene Symbol

MBD2

Gene Synonyms

DMTase
NY-CO-41

Gene Full Name

methyl-CpG binding domain protein 2

Gene Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

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Molecular Weight(MW)

43 kDa

Cellular Localizatio

Nucleus

Application

·        

WB

Western blot analysis using MBD2 antibody against K562(1), Raji(2) cell lysate.

·       

IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using MBD2 antibody with DAB staining.

·        

ICC/IF

Immunofluorescence analysis of MG-63 cells using MBD2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500

Additional Information

Form

Liquid

Storage Instruction

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azide.




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