Product Profile

Product Name	Anti-SOCS3 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHC
	IHC:1:200-1:1000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	SOCS3
Gene Synonyms	CIS3 SSI3 ATOD4 Cish3 SSI-3 SOCS-3 Hide
Gene Full Name	suppressor of cytokine signaling 3
Gene Summary	This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. Hide
Molecular Weight(MW)	25 kDa
Cellular Localizatio	Cytosol

Application

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IHC

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using SOCS3 antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using SOCS3 antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of A549 cells using SOCS3 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

IHC:1:200-1:1000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.