|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-09-11
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
WARTS
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LATS1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
LATS1
Gene Synonyms
wts
Gene Full Name
large tumor suppressor kinase 1
Gene Summary
The protein encoded by this gene is a
putative serine/threonine kinase that localizes to the mitotic apparatus and
complexes with cell cycle controller CDC2 kinase in early mitosis. The
protein is phosphorylated in a cell-cycle dependent manner, with late prophase
phosphorylation remaining through metaphase. The N-terminal region of the
protein binds CDC2 to form a complex showing reduced H1 histone kinase
activity, indicating a role as a negative regulator of CDC2/cyclin A. In
addition, the C-terminal kinase domain binds to its own N-terminal region,
suggesting potential negative regulation through interference with complex
formation via intramolecular binding. Biochemical and genetic data suggest a
role as a tumor suppressor. This is supported by studies in knockout mice
showing development of soft-tissue sarcomas, ovarian stromal cell tumors and
a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Hide
Molecular
Weight(MW)
127KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton
Application
ICC/IF:1:100-1:500
WARTS
·
IHC
Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using lats1 antibody with DAB staining.
·
IHC
Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using lats1 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of C2C12 cells using lats1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
IHC:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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