Product Profile

Product Name	Anti-LMNA antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHCWB
	WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	LMNA
Gene Synonyms	FPL IDC LFP CDDC EMD2 FPLD HGPS LDP1 LMN1 LMNC MADA PRO1 CDCD1 CMD1A FPLD2 LMNL1 CMT2B1 LGMD1B Hide
Gene Full Name	lamin A/C
Gene Summary	The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022] Hide
Molecular Weight(MW)	74KD
Cellular Localizatio	Intermediate filament, Nucleus

Application

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WB

Western blot analysis using LMNA antibody against HepG2(1) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded colon cancer tissues tissues using LMNA antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of C2C12 cells using LMNA antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.