|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-09-11
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
· 
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
· 
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
LDLCQ3
LGMDR28
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-HMGCR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
HMGCR
Gene Synonyms
MYPLG
Gene Full Name
3-hydroxy-3-methylglutaryl-CoA reductase
Gene Summary
HMG-CoA reductase is the rate-limiting
enzyme for cholesterol synthesis and is regulated via a negative feedback
mechanism mediated by sterols and non-sterol metabolites derived from
mevalonate, the product of the reaction catalyzed by reductase. Normally in
mammalian cells this enzyme is suppressed by cholesterol derived from the
internalization and degradation of low density lipoprotein (LDL) via the LDL
receptor. Competitive inhibitors of the reductase induce the expression of
LDL receptors in the liver, which in turn increases the catabolism of plasma
LDL and lowers the plasma concentration of cholesterol, an important
determinant of atherosclerosis. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. [provided by
RefSeq, Aug 2008]
Hide
Molecular
Weight(MW)
97KD
Cellular
Localizatio
Endoplasmic reticulum membrane.
Peroxisome membrane.
Application
ICC/IF:1:100-1:500
LDLCQ3
LGMDR28
·
IHC
Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using HMGCR antibody with DAB staining.
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using HMGCR antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of MG-63 cells using HMGCR antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
IHC:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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