Product Profile

Product Name	Anti-TMS1 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHC
	IHC:1:200-1:2000
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	PYCARD
Gene Synonyms	ASC TMS TMS1 CARD5 TMS-1 Hide
Gene Full Name	PYD and CARD domain containing
Gene Summary	This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Hide
Molecular Weight(MW)	22KD
Cellular Localizatio	Cytoplasm

Application

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IHC

Immunohistochemical analysis of paraffin-embedded colon cancer tissues using TMS1 antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using TMS1 antibody with DAB staining.

Application Notes

IHC:1:200-1:2000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.