Product Profile

Product Name	Anti-DYNLL1 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHC
	IHC:1:200-1:2000
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	DYNLL1
Gene Synonyms	LC8 PIN DLC1 DLC8 LC8a DNCL1 hdlc1 DNCLC1 Hide
Gene Full Name	dynein light chain LC8-type 1
Gene Summary	Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Hide
Molecular Weight(MW)	11KD
Cellular Localizatio	Cytoplasm, Cytoskeleton, Dynein, Microtubule, Mitochondrion, Nucleus

Application

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IHC

Immunohistochemical analysis of paraffin-embedded colon cancer tissues using DYNLL1 antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded breast cancer tissues using DYNLL1 antibody with DAB staining.

Application Notes

IHC:1:200-1:2000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.