Product Profile

Product Name	Anti-GHR antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHCWB
	WB:1:200-1:2000 IHC:1:200-1:2000
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	GHR
Gene Synonyms	GHBP GHIP
Gene Full Name	growth hormone receptor
Gene Summary	This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] Hide
Molecular Weight(MW)	72KD
Cellular Localizatio	Cell membrane, Membrane, Secreted

Application

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WB

Western blot analysis using GHR antibody against Hek293(1), A431(2) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded liver cancer tissues using GHR antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded breast cancer tissues using GHR antibody with DAB staining.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:2000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.