Product Profile

Product Name	Anti-LRP5 antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAICC/IFIHC
	IHC:1:200-1:2000 ICC/IF:1:100-1:500
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Protein A

Target Information

Gene Symbol	LRP5
Gene Synonyms	HBM LR3 OPS EVR1 EVR4 LRP7 OPPG BMND1 LRP-5 LRP-7 OPTA1 PCLD4 VBCH2 Hide
Gene Full Name	LDL receptor related protein 5
Gene Summary	This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Hide
Molecular Weight(MW)	180KD
Cellular Localizatio	Endoplasmic reticulum

Application

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IHC

Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using LRP5 antibody with DAB staining.

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IHC

Immunohistochemical analysis of paraffin-embedded breast cancer tissues using LRP5 antibody with DAB staining.

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ICC/IF

Immunofluorescence analysis of A549 cells using LRP5 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes

IHC:1:200-1:2000 ICC/IF:1:100-1:500

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.