Product Profile

Product Name	p-CREB-2 Antibody (Ser 245)
Antibody Type	Primary Antibodies
Modification Notes	Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis-acting promoter and enhancer elements. The cAMP response element (CRE), one of the best studied of such elements, consists of the palindromic octanucleotide TGACGTCA. Several CRE binding proteins have been identified within the ATF/CREB family, the best characterized of which include CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. These proteins share highly related COOH terminal leucine zipper dimerization and basic DNA binding domains but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins appear capable of binding CRE in its homodimeric form, certain of these also bind as heterodimers, both within the ATF/CREB family and even with members of the AP-1 transcription factor family.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	IFIHC
	recommended for detection of Ser 245 phosphorylated CREB-2 of h origin by IF and IHC(P):
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Alternative Names	epitope corresponding to phosphorylated Ser 245 of CREB-2 of human origin
Tissue Specificity	epitope corresponding to phosphorylated Ser 245 of CREB-2 of human origin

Database Links

Entrez Gene

468

Application

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Application

Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue extract showing nuclear localization.

Application Notes

recommended for detection of Ser 245 phosphorylated CREB-2 of h origin by IF and IHC(P):

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20oC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.